A truck jack-knifed on the Great Western Highway at Springwood about 12.20am on Thursday.
Blue Mountains Police Inspector Ian Colless said the semi-trailer carrying fruit and vegetables was east-bound when the driver lost control near the Hawkesbury Rd overbridge.
The driver sustained minor injuries.
Diversions were in place until 6.30am when the highway was officially reopened.
Inspector Colless said police were investigating the cause of the accident.