Erin Burns and Heather Graham are in line to make their Australian debuts next month after being called up for next month's limited-overs series of West Indies.
Burns and Graham were on Friday named in a 14-player squad for the three one-dayers and Twenty20s, which will serve as crucial preparation for next year's home T20 World Cup.
They come in at the expense of Sophie Molineux and Elyse Villani, while Nicole Bolton was also unavailable for selection following the Ashes series win.
Graham is seen as one of the country's next big talents, having come through the ranks in Western Australia.
The 22-year-old allrounder was the domestic player of the year last season, topping the run-scoring lists in the 50-over competition with 294 at 49 and taking 11 wickets at 20.
Meanwhile Burns' selection is a reward for persistency.
The NSW junior has spent more than a decade playing for Tasmania and ACT after being unable to crack the Breakers side as a junior.
The offspinner had a stellar Big Bash season with 11 wickets at 15.45, and is a like-for-like replacement for Molineux in the squad.
"Erin has also been a stand out performer at domestic level and has had to bide her time for a national call-up," chief selector Shaun Flegler said.
"(Heather)'s skills with the ball will add further depth to the team's pace bowling stocks while her batting ability could see her play an important role in the middle-order."
Flegler said Molineux's shoulder had been given time to recover, while Villani had been left to find her form in the opening round of the Women's National Cricket League.
Australia have a jam packed summer, which include home series with Sri Lanka, India and England before the World Cup.
"These selections reinforce our desire to select players with a view to the T20 World Cup next year who offer versatility, can play a designated role and offer skills in a number of different facets of the game," Flegler said.
AUSTRALIA'S SQUAD: Meg Lanning (capt), Erin Burns, Nicola Carey, Ashleigh Gardner, Heather Graham, Rachael Haynes, Alyssa Healy, Jess Jonassen, Delissa Kimmince, Beth Mooney, Ellyse Perry, Megan Schutt, Tayla Vlaeminck, Georgia Wareham.
Australian Associated Press